Questions about "luxury" shirting

[Thomas Auer]

What would you consider to be the sweet spot between the fully handmade shirts and machine-made shirts, assuming they use the same fabric?

Little late response, but I think it's fair to say that from a technical stand point, very few hand operations add anything of substance to the construction of a shirt (although many will tell you otherwise). Also, no handmade armhole will last as long or stay as clean, as proper machine stitching. I really like the aesthetic of a handmade buttonhole or shoulder and armhole seams, so that, to me, is the only reason for doing it. It should also be mentioned that the quality of hand sewing varies drastically between makers and all too often, it really looks messy. If you want something handmade and done - for example - in Europe(other than the south of Italy) you will easily approach the 300€ mark