- Nov 10, 2006
- Reaction score
I've never understood this, but it happens every time.
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The fructose content can also have an effect on leptin signals, which regulate hunger.
It's not really going to have that great of an effect in the short term on Leptin.
Because insulin and leptin, and possibly ghrelin, function as key signals to the central nervous system in the long-term regulation of energy balance, decreases of circulating insulin and leptin and increased ghrelin concentrations, as demonstrated in this study, could lead to increased caloric intake and ultimately contribute to weight gain and obesity during chronic consumption of diets high in fructose.
While I agree chronic consumption will definitely pose more of an effect than acute ingestion of fructose, the fact that fructose lowers circulating levels of leptin certainly can be a contributing reason as to why he's feeling hungrier. I'm just hypothesizing here.
You don't really see sustained (or imo physiologically significant) differences until after the consumption of the second high fructose meal. Look up this paper "Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals" by Stanhope et al. and you'll see the same thing.
You don't really see sustained (or physiologically significant) differences until after the consumption of the second meal.