At your age, I'd adjust 20% of your portfolio for trading/speculative purposes. It would require your time, otherwise don't. Cherry picking diminishes the more data points you have. It's one reason I trade such a large body of stocks. When my stuff isn't moving with the market trend, I'm out of sync, and I have data to show it. Then I have to decide if my conviction is strong enough to think its a blip, or whether it's time to shift. I was out of sync 6 or 8 months ago, but I held to my conviction that this was a momentum market and biotech was leading the way. I believe I was right, maintain, and have added to my conviction. It's coming to roost with RHHBY's recent acquisition. I think there will be as widespread acquisition spree of young biotech names and I intend to be there for at least 1 or 2 hits.