R6, all I can give is anecdotal evidence about the Lexus since I've never driven in the Buick, but my mom owned and still owns an RX330. It's been on a bunch of road trips, including a few snowboarding trips I've taken it on in New Hampshire/Vermont/Maine. It's always performed well in the snow/rain/sleet all that good stuff, and was comfortable for hauling winter gear for me and 2 buddies. 4 guys total would be pushing it. Turning radius isn't so great but I doubt you'll be doing much maneuvering in tight parking lots and parallel parking. That said, it is exactly like you would expect a Lexus to be. Nothing noticeably spectacular but fullll of little conveniences that you would never have expected that make it overall a good A to B car. Fit and finish is great, we've done nothing but routine mainteance, and that includes changing the timing belt at 130,000 miles. Not a big deal though. Gas mileage is good, and the car is peppy enough. I noticed you're looking at the RX350 though - it's a little bigger, the ride is a little softer, but it does have one big drawback and that is the navigation. It's no longer touch screen for whatever reason and is surrounded by all these awful buttons. The old system is absolutely great so I have no idea why they changed it. That would be a total dealbreaker for me, unless the buick also has a bad navigation system. We also used to have an RX 300, but those are basically little turds now and I can't ever see looking back. My favorite snowboarding trip vehicle ever was definitely an '01 Tahoe, but gas mileage on that was kind of shitty. Moved me in and out of a few places though, but fit and finish on it was total crap. Also the car I was in the attempted carjacking with, lol.