This is the exact problem I have with interviewers. They either don't believe I want out or don't believe I'm capable of doing something else. Why is that so hard to believe? Changing industries is definitely possible, all the more so if they're somewhat related and/or complementary. I've gone from information technology to medical devices to pharma devices & diagnostics. As with most things in life, you need a proper narrative so that your prospective employer actually perceives your previous experience as making you uniquely valuable. On a related note, simultaneously changing your functional role in a different industry is more difficult, while doing both and changing geographies is harder yet. A person's likelihood to excel in the new role is typically inversely proportional to the degrees of separation away from his/her core competencies (although the rewards may make the risks worthwhile). YMMV.