From your list, I would omit: H&M (cheap chain merchandise) Gilroy Outlet Centre (not worth the hour+ drive each way) Metreon (it's being renovated, it's basically a glorified movie theater now, and it's kinda thuggish these days) Rainforest Cafe on Fisherman's Wharf (there's nothing particularly San Francisco about this place) Strongly recommend: Alcatraz Golden Gate & Fort Point Lombard street (As long as you don't go on a weekend afternoon, the wait isn't that bad. Try coming up Hyde Street and turning right instead of going directly up Lombard) Academy of Sciences Twin Peaks Lookout (On a clear day, there is probably no better vantage point in the city) Mission (Walk Valencia from Division to 24th Street and check out the galleries and shops. Then eat at Papalote at 24th and Valencia) Exploratorium at The Palace of Fine Arts (I love it, and my kids love it, too) Meh: Fisherman's wharf &Pier 39 De Young Museum Lombard street - really worth it??? Chinatown Alamo Square Park While you're in town, try to have brunch at Nopa in the Western Addition. Best French toast I've ever had. Hands down. The burger is also ridiculously good.