I am 6-6.1", I would like to be in the 180 range,maybe I could get down to 175 but wouldn't really want to go any further as I did that before and didn't really feel good. I think that if I can keep the weight in the 175-180 range,I should be fine. I didn't realize that even couple of pounds can be crucial,that's good to know. I also think that I need to build up slowly,I wasn't running during the colder days,was just too lazy and plus the cold killed all the desire, I probably need to start slowly and add 10% every week. Also going to a store to get fitted this week, I usually bought Asics running shoes based on my own research but never had the professional fitting done so it may improve things for me. I agree that dropping a few pounds and going gradually is the way to go. As for shoes, getting fitted should help you avoid excess pronation which is tough on your knees - but only someone who's watching you will be able to discern whether that's even an issue: some people don't have that issue. Since you're 180+ you may get pushed into the heavier shoes, which may or may not be appropriate for your gait, etc. But if you go with a lighter shoe, definitely get a second pair to rotate: wearing the same shoe on consecutive days will wear your legs out.