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Have you been to a "Rave"

Discussion in 'Social Life, Food & Drink, Travel' started by Vaclav, Mar 22, 2006.

  1. johnapril

    johnapril Senior member

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    Is X metabolized by CYP3A? If so, take with grapefruit juice or ketoconazole to enhance the effect.
     
  2. romafan

    romafan Senior member

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    NYC
    Possibly sadder are the men, usually heterosexual, who give blowjobs in bathrooms for a trip of whatever. I've been tempted to get them some so they won't feast on a filthy appendage for just a night. Logic ends up prevailing over sympathy but still.

    On the flip-side, a very strange practice I read about is hetero bikers (I think they were Hells Angels) who would allow gay men to fellate them for a fee..[​IMG]
     
  3. johnapril

    johnapril Senior member

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    Uop. No. 2D6:

    "Ecstasy" [(+/-)-3,4-methylenedioxymethamphetamine or MDMA] is a CNS stimulant, whose use is increasing despite evidence of long-term neurotoxicity. In vitro, the majority of MDMA is demethylenated to (+/-)-3,4-dihydroxymethamphetamine (DHMA) by the polymorphic cytochrome P450 2D6 (CYP2D6). We investigated the demethylenation of MDMA and dextromethorphan (DEX), as a comparison drug, in reconstituted microsomes expressing the variant CYP2D6 alleles (*)2, (*)10, and (*)17, all of which have been linked to decreased enzyme activity. With MDMA, intrinsic clearances (V(max)/K(m)) in CYP2D6.2, CYP2D6.17, and CYP2D6.10 were reduced 15-, 13-, and 135-fold, respectively, compared with wild-type CYP2D6.1. With DEX, intrinsic clearances were reduced by 37-, 51-, and 164-fold, respectively. It was evident that CYP2D6.17 displayed substrate-specific changes in drug affinity (K(m)). Compounds potentially used with MDMA [fluoxetine, paroxetine, (-)-cocaine] demonstrated significant inhibition of MDMA metabolism in both human liver and CYP2D6.1-expressing microsomes. These data demonstrate that individuals possessing the CYP2D6(*)2, (*)17, and, particularly, (*)10 alleles may show significantly reduced MDMA metabolism. These individuals, and those taking CYP2D6 inhibitors, may demonstrate altered acute and/or long-term MDMA-related toxicity.
     
  4. johnapril

    johnapril Senior member

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  5. VMan

    VMan Senior member

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    A buddy has been talking about getting some E for tonight, but hasn't done it before. What should he know to be safe?
     
  6. whoopee

    whoopee Senior member

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    Well, if he's set on doing it, make sure he doesn't drink any alcohol while high (people have died from mixing), has plenty of water on hand, dresses coolly, and buys only from a "reputable" dealer.
     
  7. VMan

    VMan Senior member

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    My friend says its fucking amazing and it's the happiest he's ever been.

    He is also dancing like a damn villain in the livng room as I type.

    The sound surrounds me like Dolby 5674.1 surround sound.
     
  8. imageWIS

    imageWIS Senior member

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    Location:
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    Uop. No. 2D6:

    "Ecstasy" [(+/-)-3,4-methylenedioxymethamphetamine or MDMA] is a CNS stimulant, whose use is increasing despite evidence of long-term neurotoxicity. In vitro, the majority of MDMA is demethylenated to (+/-)-3,4-dihydroxymethamphetamine (DHMA) by the polymorphic cytochrome P450 2D6 (CYP2D6). We investigated the demethylenation of MDMA and dextromethorphan (DEX), as a comparison drug, in reconstituted microsomes expressing the variant CYP2D6 alleles (*)2, (*)10, and (*)17, all of which have been linked to decreased enzyme activity. With MDMA, intrinsic clearances (V(max)/K(m)) in CYP2D6.2, CYP2D6.17, and CYP2D6.10 were reduced 15-, 13-, and 135-fold, respectively, compared with wild-type CYP2D6.1. With DEX, intrinsic clearances were reduced by 37-, 51-, and 164-fold, respectively. It was evident that CYP2D6.17 displayed substrate-specific changes in drug affinity (K(m)). Compounds potentially used with MDMA [fluoxetine, paroxetine, (-)-cocaine] demonstrated significant inhibition of MDMA metabolism in both human liver and CYP2D6.1-expressing microsomes. These data demonstrate that individuals possessing the CYP2D6(*)2, (*)17, and, particularly, (*)10 alleles may show significantly reduced MDMA metabolism. These individuals, and those taking CYP2D6 inhibitors, may demonstrate altered acute and/or long-term MDMA-related toxicity.


    I think I just experienced the same sort of mental unawareness you get from X (not that I would know), just from reading that whole thing.

    Jon.
     
  9. LabelKing

    LabelKing Senior member

    Messages:
    25,745
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    Location:
    Constantinople
    Possibly sadder are the men, usually heterosexual, who give blowjobs in bathrooms for a trip of whatever. I've been tempted to get them some so they won't feast on a filthy appendage for just a night. Logic ends up prevailing over sympathy but still.
    Nan Goldin will be there.
     

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