My vote's for GTA IV, so far. I feel like since it was released earlier in the year, a lot of people are sleeping on it. Gears of War 2 as well. But I have Fable 2 and Fallout 3 waiting in the wings, so who knows how I'll feel after playing them.
I still am pouring a lot of time into Madden. Franchise, playing online, playing in EA's online
"Champions of Gaming" tournament... can't get enough, especially not during the playoffs.