I just tried some of the Makers 46 this weekend. Wasn't bad - to me, it definitely tasted nothing like the standard Makers, which I believe has little to no rye. The 46, on the other hand, was definitely spicy - kind of like Bulleit, but sweeter. Definitely not bad, but not my favorite to drink neat. I ended up adding a splash of water to take off some of the roughness, and it was a bit more enjoyable. Given its spiciness, it'd probably make a decent Manhattan in a pinch (if no rye is available). I wouldn't order it again, but definitely worth trying if you get the chance.
Its pretty interesting. I don't love it, but I like it better than regular Makers. The extra spiciness is achieved not by upping the rye in the mashbill, but by dropping some staves of French oak into barrels of regular Makers and aging them for an extra 10 - 11 months or something like that.