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Originally Posted by
redgrail 
Firstly: anyone with any background in science can tell you self-reporting survey-based studies are no replacement for lab testing.
Secondly: the NCI study was over a twelve month period. The Ramazzini study which tested sweetener consumption in lab animals (rats, specifically) was over a life span. The deleterious effects of long-term ingestion have not been disproven.
Debunked is a strong word to use, especially in the natural sciences. No statistical link was shown in a large survey-based study that tracked consumption over a twelve month period in humans. This is true. However, because of the results of the Ramazzini study, I would still advise exercising caution.
I know this is a jungle of research and must be hard to navigate. But anything that's caused this much controversy is likely something you want to limit your consumption of.
Agreed, I'll definitely be dumping diet drinks based on their effect on insulin secretion. And you are right, I shouldn't have said "debunked".
There has been a fair amount of controversy over the Ramazzini study though. Unless independent groups corroborate their results, you can't really depend on them particularly given the criticisms of their methodology.
http://en.wikipedia.org/wiki/Asparta...ini_Foundation
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In August 2007, the New Zealand Food Safety Authority (NZFSA) published a press release commenting upon the Italian study:
" \t... These studies were conducted in a way that could not possibly have provided any information about the toxicity of aspartame - or in fact anything else in the rats' diet. The animals used were allowed to live until they died naturally, meaning that all the study did was show the results of ageing, which as we all know is a natural process that leads, inevitably, to death.
In fact, the only conclusion that can be drawn from the results is that aspartame appears to be safe because the studies showed that those rats fed it (even at very high doses) lived as long (if not longer) as untreated rats, despite consuming up to more than 100 times the ADI every day of their lives. If aspartame was as horrendously toxic as is being claimed, it would be logical to expect the rats dosed with it to have shortened life-spans. The conclusions drawn by the researchers were clearly not backed up by their own data.[72]