Your opinion of Duane Reade would be totally turned on its head if you lived in Brooklyn. Soon you realize everything at DR is 1/2 the size of Target or Key Food and 2x the price, for the same brand. Occasionally DR has some good markdowns on cleaning supplies, but in general Target wins.
Continuing on this theme: Trader Joe's is a death trap where you are liable to be crushed by the checkout queue that you must enter immediately upon walking into the store. Hopefully you can reach your items from the path of the line. Both Agata & Valentina locations are filthy, Citarella is only marginally better. I typically go to Fairway on 6 Av or Red Hook if my neighbor is driving over there. Whole Foods Markets are also a death trap except for the Bowery and Gowanus locations, which are rather manageable if you don't go on a weekend.
If you go anywhere near downtown Brooklyn and are not white, you can expect to be accosted by people on the street for "looking good/being well dressed". This has happened to me at least 4 times when walking from Atlantic Terminal to the only Chase ATM in the entire area near Nevins St.