I do a lot of international business traveling from the US to Europe and Asia. I'm typically gone from two weeks to two months. Unfortunately, it's not easy to travel light when you need to wear a suit and tie for work every day. I usually take two suits -- blue pinstripe and gray, a navy blazer, two or three pairs of Dockers & odd trousers and six dress shirts. Travel business shoes are usually rubber soled since they put up with rain better than my nice leather soled AEs. Add a trench coat, sox, underwear, shoes and belts, and it all adds up.
My travel luggage consists of a large hard-sided suitcase on wheels. I purchased Carlton in HK (hard to find in the US), but any well-made brand will do. I pack my suits, shirts, ties and other nice stuff in the large suitcase. The large suitcase has no liquids or metal objects -- I don't want to give security a reason to open it and mess up my nice packing. I pack shoes, toiletries, sox, underwear, casual clothes, etc. in a smaller roll-on bag. If security opens this one and does not fully close a contact lens bottle (this has happened) then my nice clothes don't get ruined. All liquid bottles are in zip lock bags which get an extra level of protection. The small roll-on is nice to have if I need to do a day trip from my primary destination. Both bags get checked.
Carry on is a small leather messenger style briefcase with laptop, charger, phone, meds, contact case, glasses, documents, etc.
This has worked well for me for 20+ years of international business travel.
Edited by Twotone - 7/29/12 at 2:27pm