If we being serious, I would stock menswear and womens mid-priced brands of clothing, shoes, and accessories. Mainly from American designers that I like but still have some basic market appeal. Not too out there that it would "offend people" but not too pedestrian that customers would complain about the 230 dollar blouse. Important for the names to ring a bell as well since customers would correlate popularity or the "vogue effect" to quality.
Men: Ben Minkoff, Robert Geller, Rachel Comey (footwear only), Phillip Lim, Alexander Wang, NikeGyakusou, Patrik Ervell, Siki Im, Zero+Maria, Common Projects
Women: Gary Graham, Reed Krakoff, Rachel Comey (whole collection), Zero+Maria, Phillip lim, Alexander Wang (well he brings money), Patrik Ervell, Jeffrey Campbell (money), Tory (uh huh), Pamela Love, Theyskens' Theory
Probably a few brands from overseas that I think would work in the area given the chance: Chronicles of Never, Carin Wester, Schneider, Dr. Martens (the cash flows), McQ (name recognition), Chris & Tibor, Nike Gyakusou, Raf Simons 1995, etc etc
I love candy so candy shop with a mini-book stand would be very interesting. Though the magazines I read don't use nearly any of the listed brands I would stock; 10 men, fantastic man, gentlwoman, elle collections UK, Industrie, Acne Paper. Running weekly workshops would be interesting and keep the store in the news.
The real factor is price and location. If I was in Baltimore it would be impossible to sell brands like Dries, Celine, McQueen, Narciso Rodriguez, Juun J, Missoni, Undercoverism, The Row, and Marni. My stocklist is also too long but I just felt like covering all bases and keeping too about 2-3 aesthetics max for the overall store.