Game owns. It owns pretty hard, that being said... a few gripes:
Inventory management
Jumping puzzles
REALLY, REALLY EASY.
Also, the game really really really favours stealth over combat. Gunning everything down leaves you with no ammo and dead shortly thereafter, whereas going the stealth route even without the stealth augs is ridiculously easy. I don't have any of the quiet walking or LoS/noise visual aid stealth thingies, and sneaking around is stupid easy. Getting the ghost achievement is almost a given if you have a working brain and some patience. I got the social aug and maxed my hacking asap and the game has been pretty easy. I think I'll try another playthrough trying to kill absolutely everything; I feel it'll be much harder.
Game thus far: break a wall/hack a terminal/fall into an otherwise unreachable area. Crawl through vent. Sneak up on guard(s), hold Q and kill. Hack now accessible terminal. Continue on to next area. Sneak up, hold Q, kill. Hack next terminal, crawl through another vent. Talk to NPC. etc. etc.
That being said, the game is awesome and is a great successor to the first. I remember reading absolutely every newspaper and geeking out over all of the lore and conspiracy in the first one - its nice to be able to put together the story by yourself via logs/newspapers/ebooks/pocket secretaries and whatnot. I have a notepad and I write down who is emailing who and whatnot - it really makes the story shine when you get that "ohhh snap" moment after reading a sneaky email or something.