Cuffs are one of those rare items of men's fashion for which the rules are essential none (excluding them being forbidden on formal wear of most sorts).
Do as you please to suit your build and the overall aesthetic you are trying to acheive.
I can promise one thing - no matter what you do in this regard you will either have to change them all out every few years or accept the fact that your choice will be 'out of fashion' sometimes. As in terms of fashion it all cycles about endlessly. I've been dressing for the office for thirty years and I can promise you I've worn everything from triple pleated and cuffed to slim fitted and no cuff and everything in between. To me this all fine when buying trousers as separates. For suiting I try to keep pretty near a 'middle ground' and avoid extremes - medium leg openings, no cuffs on anything at the moment - although am thinking a few with cuffs would be nice.
The current 2" cuff look is fun - but a flash in the pan that will be over soon enough.
The good news is that cuffs can be adjusted readily - so when fashions change - so can you!