Ah, Philly...spent the best four years of my life there.
Barclay Prime for steak; Royal Tavern for burgers and wings; Monk's or Eulogy for beer; Franklin or Time for cocktails; Pat's for cheesesteaks at 4am (Jim's is better but closes at 2 or 3). Wake up and head to Morning Glory Cafe for brunch and you're good to go.
I'm leaving out quite a bit here (NoLibs, for starters -- can't go wrong with North 3rd or Standard Tap)...Philly is an epic eating and drinking city, though.