random is the way to go, but there are ways to optimize when it comes to a mega jackpot like this where a ton of tickets could easily be sold with lots of overlaps.

You are trying to maximize the expected value of your own ticket. Each ticket has an even chance of winning...but if one other person has the same numbers, your expected value is instantly cut in half.

If you pick 1 2 3 4 5 6...I guarantee there are a 100 other people who thought it would be funny if it won...now you get a lump sum of 9m instead of 900m.

Quick Pick is pretty good. Random is better than not-random...but there are lots of crazy people (we are talking about lottery players here) who don't make random picks. Avoiding their numbers doesn't change your odds at all, but it can slightly increase your expected value.