+1 on Rome and Boston Legal both. Star Trek: just when I started to get into the last one--Enterprise--it was over. I failed to appreciate Voyager at the time it aired. (A shame, since I've enjoyed watching re-runs of it since, though laugh a bit today sometimes when I see re-runs of TOS which as a kid I truly loved). I agree with Manton that DS9 had pretty much run its course (it was a good series), but was sad to see TNG go. (I know, certain actor(s) left and/or wanted more money which wasn't possible given the demographics--i.e., a loyal following but no room for audience growth, thus resulting in cancellation of the show, as I recall.) To the list I'll add the X-Files, although it probably should have ended long before it did (after David Ducovny left (Mulder), it was all downhill; the movie finale in which he returned was, however, good). Another is the original Law & Order (the "mothership"), although that show had likewise run its course--and what an amazing run it was. (I loved the show in the beginning, being based on real cases, though I don't care much for the spin-offs). EDIT: just thought I'd add one that I don't miss: Ally McBeal.