In SanFo? Good luck with that.
I don't know what "youthful culture" is but it sounds horrible.
I would move out to the fringes. Maybe here: https://maps.google.com/maps?hl=en&q=farallon+islands&ie=UTF-8&hq=&hnear=0x8085e2b7910a1ba3:0xdc331bc6012c791a,Farallon+Islands&gl=us&ei=p9dIUfGjIdPF4AOX64CYBg&ved=0CIcBELYD
Everyone says the Marina is for college preppies, and I can verify that North Beach has way too many tourists, at least for my taste. Unless this is a short-term thing, I'd recommend Pacific Heights if you have the bucks, otherwise Cole Valley or Noe Valley.