I've used the Osprey Porter 46 as my only bag, and have been able to carry it on to all North American flights so far. If I'm planning on taking any formal wear, that means that I'll be wearing the jacket while traveling, since I wouldn't want to cram it into the bag with the other items. If you want to pack your suit or blazer, you may want a different system. In case the bag is ever rejected as a carry-on, I pack an ultralight nylon daypack so I can always have my essentials with me on the airplane. (Consider what you can get by with if that's all you have, as well as what could be the most help in an emergency.) There are many ultralight packs on the market that double as stuffsacks. The Porter 46 has semi-rigid foam sides, which help maintain the bag's shape when it's not full or when the contents have irregular shapes. This in turn helps with comfort when carrying the bag, and in packing/unpacking/finding items quickly. The downside is that the bag may not be as crammable as completely unstructured bags -- it may require a bit of a shove to fit it into bins and other small spaces; but it's not so stiff that it won't respond to a good push. Slash pockets on the Porter 46 are another comprimise. They give the bag a clean profile (you might say snag-free) and help keep the weight close to your back for bettery carrying comfort. Patch pockets such as seen on many rectangular bags and most military styles would have been a more bulky option, but might have provided somewhat better quick access to small items. Which do you prefer? All in all, I find the Porter's construction durable and the design logical. The handles and straps are very comfortable. Compression straps are very adjustable and well thought-out. Add a couple of lightweight mesh 'cubes' for organizing clothing, and a few ziplocs to keep other loose items together, and you have a lightweight, easy-access system. If you pack with efficiency in mind, holding to one colour scheme and a few multi-use essentials (e.g., cashmere or merino sweater!), you can leave a lot of weight in duplicate clothing at home. I also forego packs with wheels; I want my carry-on light enough to be carried anywhere. A light pack not only gives me comfort, it enables me to adapt on the spur of the moment, catch connections others would miss, and opt for adventurous side trips others would be too encumbered to consider. More reviews:
http://www.dailyhiker.com/gear/osprey-porter-46/