On my recent trip up I stayed at The Gershwin (http://gershwinhotel.com/)
. Besides the Warhol self-portrait / signed Cambell's soup can in the lobby and the very hot French girl working the front desk, I would recommend nobody ever stay there despite the appealing price and artwork. Shoddy rooms (we had a suite and even still it reminded me of the terrible dorm rooms I had at overseas soccer school), water temp. in the showers that range from too cold to way too hot (I almost killed myself one time trying to escape a scalding), the linens were harsh, wi-fi didn't work properly, never gave us enough towels, pethetic coffee bar in the lobby is expensive, the remote for my room didn't work (the TVs are Samsung LCD panels so you need a remote to switch channels), never gave me the wake up call I requested and ended up getting jipped on the parking. I'm probably missing a few points. It is however located next to The Museum of Sex, so yeah, there's that...
For my November trip I'm staying at Chambers (http://www.chambershotel.com/
) which comes highly recommended by a lot of jet-setters and immediately seems swank by just looking at the accomodations. If money is no object you may want to check it out.