true story: when i first worked at the north end of downtown, i was in an office between spring and main. the loading dock on the alley out back was the smoking deck and there were actually people who quit smoking because the stench of urine, etc. from the alley was so bad they couldn't stand it. of course, now that very spot is the entry way for the edison. it's hard to believe how much downtown (at least some parts) have changed. but, yeah, get down around san pedro/alameda ... toy district, fish district, north part of fashion district ... close to the missions, and it's still very iffy.