1) The old school bodybuilding practice of eating small meals every 3 hours seems superior for muscle growth in comparison to "normal eating" or Intermittent Fasting. This, because the body can only use so much protein for maximum stimulation of MPS per instance (meal) (actual number is ~0.25g protein/kg BW per meal, which is often much lower than many lifters eat).
2) The almost mythical bodybuilding practice of waking up in the middle of the night to eat, seems rational since sleep is the time where we "lose" most muscle (MPB surpasses MPS). This negative effect can however be mitigated with a higher dose (40g, or 0.5g kg/BW) of slow digesting casein protein pre bed.
3) Intermittent Fasting and IIFYM or not caring about meal frequency does thus not seem to be optimal for maximum muscle growth.