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Random health and exercise thoughts - Page 3779

post #56671 of 57260
Quote:
Originally Posted by ridethecliche View Post

The effects of leptin are pretty easily overcome though. It reflects fat stores, but you get some resistance and need more to compensate.

Obviously the extreme example here is with obesity, which isn't the population were talking about.

Edit: Err sorry some tolerance in most people, resistance in obesity.
 

 

Ya, but leptin has many downstream effects with gene expression and leptin levels become increasingly important the leaner you get. Minutiae, really, but worth noting. 

 

And I dunno, some folk in this thread are what I would term obese by bodyfat but I'm an asshole and the medical definition of obese is pretty nebulous. 

post #56672 of 57260
Quote:
Originally Posted by MGoCrimson View Post

Warning: Spoiler! (Click to show)
Ok so satiety, briefly, is an interaction between the following:

Ghrelin, insulin, leptin, peptide YY, glucagon-like peptide-1, cholecystokinin, apolipoprotein AIV, and stretch receptors in the stomach. These are all anorexigenic signalling hormones/receptors except for ghrelin, which is the main "hunger" hormone. 

Protein is the most satiating macronutrient. It produces a lower insulin AUC than CHO, but has higher PYY, GLP-1, CCK, and post-meal ghrelin levels are suppressed longer compared to CHO.

Fat affects CCK and apolipoprotein AIV levels and also changes the absorption kinetics of a meal and thus has effects on the other responses. 

CHO and fat in isolation have been shown to have equal effects on satiety despite varying levels of aforementioned satiety hormones. 


But keep in mind studies are done with single macronutrient intakes. When you combine them, the story changes drastically, but the individual effects still hold. Also, the male hypothalamus has a stronger response to insulin whereas the female hypothalamus has a stronger response to leptin for energy intake regulation. 

If you're obese, your hypothalamus does not respond properly to ANY of these signals. 



Here are two good reviews on the endocrine side of it:

Appetite signaling: From gut peptides and enteric nerves to brain
http://www.ncbi.nlm.nih.gov/pubmed/17582445

The endocrinology of food intake
http://www.ncbi.nlm.nih.gov/pubmed/23877425


I can post the full texts if someone would like to suggest a decent file hosting site


Well yes, but 3 things, all somewhat related:

1. In practice you also have to consider volume and calorie density, particularly relating to its effects on the stomach stretching.
2. Fibre, fibre, fibre.
3. The effects of soluble fibre that's able to be fermented by your gut microbiota is pretty important too - in general this releases short chain fatty acids that are able to be absorbed and that also provide a satiating effect throughout the day.
post #56673 of 57260
Quote:
Originally Posted by hendrix View Post


Well yes, but 3 things, all somewhat related:

1. In practice you also have to consider volume and calorie density, particularly relating to its effects on the stomach stretching.
2. Fibre, fibre, fibre.
3. The effects of soluble fibre that's able to be fermented by your gut microbiota is pretty important too - in general this releases short chain fatty acids that are able to be absorbed and that also provide a satiating effect throughout the day.

 

Yea, this one is particularly important, but I was not aware it had an affect on satiety as well.

 

I'd also say fibre affects absorption kinetics more than anything. I realize I didn't touch on that, only fat's affect.

post #56674 of 57260
Yeah the gut/enteric nervous system stuff is fascinating. So much to learn...
post #56675 of 57260
Quote:
Originally Posted by ridethecliche View Post

Yeah the gut microbiome stuff is fascinating. So much we don't know...
post #56676 of 57260
True dat. So much interplay tho
post #56677 of 57260
There's a study that I'm really surprised hasn't been done, that I expect to be done by someone in the next few years.

1. We know that the gut microbiome falls into different sorta phenotypes.
2. We know that changes in diet can effect how the microbiome looks, quite rapidly (I believe within a week).

3. Evidence is emerging that the appendix may function as a sort of reservoir for enteric bacteria.

So, why not observe how quickly people's microbiome adjusts to a drastic change in diet comparing people who have and haven't had an appendectomy?

Would be an easy study with lots of implications.
post #56678 of 57260

You could probably do a retrospective analysis to see who needs fecal transplants and see if it correlates to an appendectomy, i.e. matched study on whether patients that have an appendectomy have a higher need for those transplants.

post #56679 of 57260
You could, sure.
But it's a really easy study for someone to do even properly.

2 stool samples per person, before and after the diet intervention. Bit of PCR and analysis, bit of stats, voila.

I should make a grant proposal.
post #56680 of 57260

I think the more interesting question is one that looks at the effect of antibiotics on recolonization of gut flora in patients with an appendix vs those that don't have one.

 

You could couple this with diet changes as well. It'd show how hardy patients can be to antibiotics use for a treatment. You can always recolonize someone with their own flora if the risk of 'offending' flora is high enough.

post #56681 of 57260
yeah antibiotics is interesting too.
post #56682 of 57260
Just looked at my weight log... down 2lbs since Monday and 8lbs in the last month lol. Hopefully only 10lbs to go... already burnt through most of my love handles and getting tricep/delt separation. This is fun
post #56683 of 57260

I'm down some weight too, but I haven't been lifting too much. Need to do a pretty big motivation reboot. I think cycling will help since I'll have more time for it once finish my first year of med school in 5 hours...

 

I also got put on ADD meds a few months ago. So that's contributed a bit to the weight loss/appetite suppression as well. I just force myself to eat and lift if I'm on it. I used to work out primarily at night, but that hasn't worked all that much lately. So it goes. Schedule's changing again in a couple of days anyway so I'll need to reboot it anyway!

 

Thanks for all the travel tips earlier. GF and I are heading to costa rica. All tickets and lodging came to like 1100 for a week long trip. Pretty psyched!

post #56684 of 57260

I'm most interested in the role the gut microbiome plays in post-prandial GI and systemic oxidative stress and inflammation as well as its possible influence on dietary choices

 

 

Now back to bro-talk: 2.5 hour shoulders and arms fluff day today. God, I love fluff days. So easy.

post #56685 of 57260
Sometimes just getting the pump is so good
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