Oh my god I would go crazy. I really need some sort of large gathering at least once or twice a week or I start to get depressed. When I was living in the suburbs for a bit I was miserable :/
Boston is a nice city, but the huge student population really homogenizes the culture so it gets boring real quick. I'd love to move to CA but I'm not in a position where I want to ditch this job right now (likely 2015 promotion)
Eh. Boston does have a sizable college population, but it's pretty thriving without them as well. I'm in my mid 20's, but I have friends in their 30's and above that love it here.
I rarely interact with students. I mean, sometimes they're there in coffee shops that I'll be in but other than that I just see them around. Not unlike any other big city.