I own
Last Night on Earth and all of the expansions. Hilarious fun. The photo art is so damn cool:

My mates and I have been playing a ton of Reiner Knizia games....
Amun-Re,
Tigris & Euphrates,
Ra, and more recently
Dream Factory. The games are very difficult to master, but really great thematically. I really want to get Samurai.
Pandemic,
RoboRally,
Warhammer: Chaos in the Old World,
Dominion,
Small World and
Rune Wars are other big favorites of ours. One of us recently got
Neuroshima Hex! which I haven't played, but people really dig it. We burnt ourselves out on the excellent, but time consuming
Battlestar Galactica game, mostly because the expansion is terrible. I'm a big
Race For The Galaxy fan. Even better is
Race For The Galaxy AI/Online which has all the expansions, online play, really REALLY good AI and it's legal (Rio Grande Games approved and gave the creator raw scans of the cards).