I am surprised no one listed Robert Geller yet, he is definitely my favorite designer at the moment, the rest are in no particular order. 1. Robert Geller 2. Wings + Horns-great cotton basics. 3. MMM-good amount of stuff, also has about the strongest line of accessories that I can think of(from shoes to jewelry and leather goods) 4. Engineered Garments 5. Alden(especially custom makeups i.e. Alden of Carmel, Leather Soul, etc.) 6. Rick Owens-Really one of the most influential American-born designers of the last ten years, I also enjoy his work for Revillon. 7. Junya Watanabe 8. Yohji Yamamoto 9. Quoddy Moccasin 10.-Edit: Temple of Jawnz, gotta give him a nod as he is offering very cool things for a very cool price.