Quote:
Originally Posted by
SuperBobo 
Reality is that we have extremly vague ideas of the actual mechanisms mediating the effect of drugs e.g., anti-depressants on illnesses of the mind/brain e.g., depression. Heck, even something as presumebly straight forward as l-dopa against parkinson is very disputed. We really dont get the workings of the neurotransmittor systems on any fine grained level.
But anyway, if clinical trials show that this or that drug works against some condition, its better than nothing (even though anti depressants really isnt that much better than placebo)...
It's because every Tom, Dick and Harry wants to do a PhD to get them into whatever fellowship they want to do, and the easiest way to do that is to just measure the effectiveness of something.
Noone wants to figure out what is actually going on when they can just do a statistical analysis, find some random statistically significant result, write a few papers and get a doctorate.
woohoo, you're now an expert on how many people this drug exhibits a positive effect in.
The best they aim for is to match the drug's effectiveness with some demographic, or if they really pulled their finger out, they found a gene that has mild association.
They still have no idea why/how though.