I find that this form of positivism is dangerous. The fact is that a large number of unknowns always exist, despite "knowledge".
Strong emotion, especially the compulsion to change, is, under all but the most favorable conditions, most likely to end in disaster. Anywhere in the world, examples are easily found.
Unknowns exist, but that's part of risk management type analysis, which is again under knowledge. Do due diligence, take action.