Have you been to a "Rave" - Page 3

A friend of mine (ok, several but a particular one I spoke to) has done a lot of coke, and he said that he has "˜no serotonin left'. What is he talking about? Does coke do the same thing as X to your serotonin level?

Jon.

Not 100% sure, but I believe coke works by blocking the dopamine receptors in the brain. Maybe over time they can get totally desensitized?

That depression thing about E is pretty true. A lot of my friends in high school were ravers, so I had first hand experience. I tried E once, and it wasn't a very potent pill at all, but I still felt it, and the after effects were definitely there. Maybe depressed isn't the right word.. it's more like an unavoidably lethargy that turns into depression because of how unavoidable it is. This is my experience, anyway. Most people where I lived were doing acid, shrooms or nitrous, not much E.

I was unaware that serotonin could be measured. Aren't most (if not all?) the studies that involve the measuring of these chemicals in the brain guess work?

All said, I've known a few people who have been more or less heavy users who seem to have experienced continuing side-effects after stopping. Whether these people were fucked up before and merely self-medicating, I don't know.

9876543210 Jon.

yes, you are right, but ecstacy depletes seratonin completely

2-4 weeks are recommended in between ecstacy drops, to give the brain time to build seratonin levels back up to a nominal level

however, i believe extended use of ecstacy (daily or even weekly) over any prolonged period of time will radically alter a person's "nominal" level, which leads to manic depression and severe bipolar disorders

One of the nicest girls in my school became a candy raver, and in between her embodiments of PLUR, went on an inexplicable criminal rampage and ended up leaving the school and community before graduation.

my friends have encountered young ladies that are otherwise very well-educated and socially secure engaging in sexual favors in exchange for a couple of e's. quite sad.

Possibly sadder are the men, usually heterosexual, who give blowjobs in bathrooms for a trip of whatever. I've been tempted to get them some so they won't feast on a filthy appendage for just a night. Logic ends up prevailing over sympathy but still.

And this is exactly why I mentioned in another post why I'm weary of having sex with anyone in the spur of the moment. Seriously, who knows what kind of shit people are carrying with them? I rater have one less sexual experience and not have a painful experience every time I pee for the rest of my life, thank you very much.

Jon.

Is X metabolized by CYP3A? If so, take with grapefruit juice or ketoconazole to enhance the effect.

On the flip-side, a very strange practice I read about is hetero bikers (I think they were Hells Angels) who would allow gay men to fellate them for a fee..

Uop. No. 2D6:

"Ecstasy" [(+/-)-3,4-methylenedioxymethamphetamine or MDMA] is a CNS stimulant, whose use is increasing despite evidence of long-term neurotoxicity. In vitro, the majority of MDMA is demethylenated to (+/-)-3,4-dihydroxymethamphetamine (DHMA) by the polymorphic cytochrome P450 2D6 (CYP2D6). We investigated the demethylenation of MDMA and dextromethorphan (DEX), as a comparison drug, in reconstituted microsomes expressing the variant CYP2D6 alleles (*)2, (*)10, and (*)17, all of which have been linked to decreased enzyme activity. With MDMA, intrinsic clearances (V(max)/K(m)) in CYP2D6.2, CYP2D6.17, and CYP2D6.10 were reduced 15-, 13-, and 135-fold, respectively, compared with wild-type CYP2D6.1. With DEX, intrinsic clearances were reduced by 37-, 51-, and 164-fold, respectively. It was evident that CYP2D6.17 displayed substrate-specific changes in drug affinity (K(m)). Compounds potentially used with MDMA [fluoxetine, paroxetine, (-)-cocaine] demonstrated significant inhibition of MDMA metabolism in both human liver and CYP2D6.1-expressing microsomes. These data demonstrate that individuals possessing the CYP2D6(*)2, (*)17, and, particularly, (*)10 alleles may show significantly reduced MDMA metabolism. These individuals, and those taking CYP2D6 inhibitors, may demonstrate altered acute and/or long-term MDMA-related toxicity.

...

A buddy has been talking about getting some E for tonight, but hasn't done it before. What should he know to be safe?