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Finasteride: keep hair & prevent cancer

post #1 of 29
2/27/09 at 8:18am
Thread Starter 
I'm one of the "guinea pigs"; I've been on finasteride >10 years to stop my hair loss (it worked!) and now I can feel better about prostate health too.

http://www.medpagetoday.com/Hematolo...=1235711222576
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post #2 of 29
2/27/09 at 10:35am
Sounds like this lowers your testosterone levels.
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post #3 of 29
2/27/09 at 12:27pm
Quote:
Originally Posted by MetroStyles View Post
Sounds like this lowers your testosterone levels.
It blocks 5-a-reductase, an enzyme that converts testosterone into dihydrotestosterone (DHT). DHT causes back and ear hair growth, male pattern baldness, enlarged prostate and prostate carcinoma.
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post #4 of 29
2/27/09 at 6:08pm
Thread Starter 
Quote:
Originally Posted by MetroStyles View Post
Sounds like this lowers your testosterone levels.

It actually raises your serum testosterone by 15%. This happens because it blocks 5 alpha reductase which is the enzymatic pathway for conversion of testosterone to DHT. Still there can be sexual side effects in around 2% of men taking it; this is about the same as the placebo control group however. As far as anabolic/muscle development is concerned, this is thought to be controlled by testosterone in humans and not DHT. Finasteride has a very short half-life and is not stored in the body; any adverse effects one might experience will quickly disappear if you quit taking it. Avodart (dutasteride), a similar drug, has an extremely long half-life and would take many months to completely clear after discontinuing it.
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post #5 of 29
2/27/09 at 6:57pm
DHT, i have it. i'm comfortable bald but kinda wish i'd taken some quasi-preventative measures.


Quote:
Originally Posted by why View Post
It blocks 5-a-hydrogenase, an enzyme that converts testosterone into dihydrotestosterone (DHT). DHT causes back and ear hair growth, male pattern baldness, enlarged prostate and prostate carcinoma.
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post #6 of 29
2/28/09 at 4:24pm
What's the deal with Proscar? Do any dermatologists prescribe it if you ask? Can you buy it from overseas without a prescription? Is that legal?
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post #7 of 29
3/2/09 at 5:46pm
Probably, yes, no (at least not in the US). To elaborate on the first answer, the closer you are to middle age, the more realistic it is that a dermatologist will prescribe you Proscar. You likely will have a better chance with a general practitioner. To answer the open-ended question about Proscar requires more specifics.
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post #8 of 29
3/2/09 at 5:59pm
I had a client who took it and it gave him gyno because all the excess testosterone that was being converted into DHT was being converted into estrogen instead.
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post #9 of 29
3/2/09 at 6:03pm
Zinc might help with that.
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post #10 of 29
3/2/09 at 6:58pm
Quote:
Originally Posted by mensimageconsultant View Post
Zinc might help with that.

With what? Even if his zinc levels were low (they aren't), adding zinc doesn't stop the aromatase enzyme. Not to mention you're dealing with endocrinology which is a hell of a lot more complex than most metabolic sciences and way beyond anyone's comprehension on this board no matter how much of a meathead they are.
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post #11 of 29
3/2/09 at 7:11pm
Damn why, breaking out the science skillz...actually, iirc there are some aromatase-inhibiting drugs, though I've never heard of them used for gynecomastia. They're basically just for a certain subset of women with responsive breast cancer.
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post #12 of 29
3/2/09 at 7:11pm
With gynecomastia. Some say zinc helps. Adding a little is unlikely to do harm.
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post #13 of 29
3/2/09 at 8:38pm
Quote:
Originally Posted by Sharlatan View Post
Damn why, breaking out the science skillz...actually, iirc there are some aromatase-inhibiting drugs, though I've never heard of them used for gynecomastia.
Arimidex et. al, I know. I realize aromatase inhibitors exist, but they're not zinc and zinc will not produce the same effect. Besides, adding an aromatase inhibitor to fix what was caused by a 5-a-reductase inhibitor can cause metabolites of who knows what and seriously mess up the endocrine system -- perhaps permanently.
Quote:
Originally Posted by mensimageconsultant View Post
With gynecomastia. Some say zinc helps. Adding a little is unlikely to do harm.
While things of this are of interest to me because I need to know what medications are and such, I never prescribe anything to clients. Like I said, the endocrine system is very complex and very powerful. Adding zinc can help with gynecomastia caused by natural hormonal imbalances (too little free T, too much estradiol, pituitary issues, whatever) but I doubt it'd reverse damage done by finasteride which if I remember correctly is a suicidal inhibitor and therefore completely shuts down the enzyme as long as it's in the system.
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post #14 of 29
3/3/09 at 12:16am
Is it true that finasteride may give you man-boobs?
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post #15 of 29
3/3/09 at 1:08am
Quote:
Originally Posted by iamprov76 View Post
Is it true that finasteride may give you man-boobs?

yup.
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