Originally Posted by bwonger06
The acetaminophen in Vicodin does not go well with alcohol (hence why people take ibuprofen for hangovers instead of tylenol). If you can, I would avoid it or take some Advil instead.
This is normally the convention because acetaminophen adds to liver damage of a hard night of drinking and, to my knowledge, has nothing to do with strange drug interactions. However, you might want to double-check.