The Pearl District in Portland is the only area that I'd live in.
I see Portland as a smaller, cleaner, less-cultured version of Seattle.
The downtown area is crammed into small blocks, so walking around is really easy. There aren't very many decent places to shop. The food is really good. There are a million strip clubs. And that pretty much sums it up.
Not the worst place to live, but I'd hold out for a better job relocation.