1st post, long time lurker.
Was lucky enough to pick up a brand new unworn 721 recently, i am a 10.5 D in most allen edmond shoes and pretty much everything else for that matter too. I bought a 10 based on the 1/2 size smaller and they fit perfect. My left foot is generally slightly wider than my right so as my feet swell sometimes it puts pressure on my ring toe but even in a 10 and at various parts of the day i didn't feel any pressure.
Hope that helps.