The aliens with the freaky mouths in the hospital were very much old school Doctor Who.
Has Rory's father been added to the cast so he can be killed off? Moffatt has indicated someone dies.
As far as River goes, her arc has already been resolved when she was trapped in the library computer back during the 10th Doctor's run. As her timeline goes in reverse I don't see exactly what they can (or should) do with her other than not bring her back as often.